Document Details
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Document Type |
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Article In Journal |
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Document Title |
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STRait Razor v2s: Advancing sequence-based STR allele reporting and beyond to other marker systems STRait Razor v2s: Advancing sequence-based STR allele reporting and beyond to other marker systems |
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Document Language |
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English |
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Abstract |
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STRait Razor has provided the forensic community a free-to-use, open-source tool for short tandem
repeat (STR) analysis of massively parallel sequencing (MPS) data. STRait Razor v2s (SRv2s) allows users
to capture physically phased haplotypes within the full amplicon of both commercial (ForenSeq) and
“early access” panels (PowerSeq, Mixture ID). STRait Razor v2s may be run in batch mode to facilitate
population-level analysis and is supported by all Unix distributions (including MAC OS). Data are
reported in tables in string (haplotype), length-based (e.g., vWA allele 14), and International Society of
Forensic Genetics (ISFG)-recommended (vWA [CE 14]-GRCh38-chr12:5983950-5984049 (TAGA)10
(CAGA)3 TAGA) formats. STRait Razor v2s currently contains a database of
2500 unique sequences.
This database is used by SRv2s to match strings to the appropriate allele in ISFG-recommended format. In
addition to STRs, SRv2s has configuration
files necessary to capture and report haplotypes from all
marker types included in these multiplexes (e.g., SNPs, InDels, and microhaplotypes). To facilitate
mixture interpretation, data may be displayed from all markers in a format similar to that of
electropherograms displayed by traditional forensic software. The download package for SRv2s may be
found at https://www.unthsc.edu/graduate-school-of-biomedical-sciences/molecular-and-medical-ge-
netics/laboratory-faculty-and-staff/strait-razor. |
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ISSN |
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1872-4973 |
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Journal Name |
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Forensic Science International: Genetics |
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Volume |
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29 |
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Issue Number |
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1 |
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Publishing Year |
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1438 AH
2017 AD |
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Article Type |
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Article |
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Added Date |
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Thursday, June 1, 2017 |
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Researchers
| King Jonathan L | Jonathan L, King | Investigator | Doctorate | |
| Wendt Frank R | Frank R, Wendt | Researcher | Doctorate | |
| Sun Jie | Jie, Sun | Researcher | Doctorate | |
| Budowle Bruce | Bruce, Budowle | Researcher | Doctorate | |
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